Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target

The β- and γ-secretase-driven cleavage of the amyloid precursor protein (APP) gives rise to the amyloid β peptide, which is believed to be the main driver of neurodegeneration in Alzheimer’s disease (AD). As it is prominently detectable in extracellular plaques in post-mortem AD brain samples, resea...

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Detalles Bibliográficos
Autores principales: Gallego Villarejo, Lucia, Bachmann, Lisa, Marks, David, Brachthäuser, Maite, Geidies, Alexander, Müller, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103247/
https://www.ncbi.nlm.nih.gov/pubmed/35563046
http://dx.doi.org/10.3390/ijms23094656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103247/
https://www.ncbi.nlm.nih.gov/pubmed/35563046
http://dx.doi.org/10.3390/ijms23094656

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