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Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target

The β- and γ-secretase-driven cleavage of the amyloid precursor protein (APP) gives rise to the amyloid β peptide, which is believed to be the main driver of neurodegeneration in Alzheimer’s disease (AD). As it is prominently detectable in extracellular plaques in post-mortem AD brain samples, resea...

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Detalles Bibliográficos
Autores principales:	Gallego Villarejo, Lucia, Bachmann, Lisa, Marks, David, Brachthäuser, Maite, Geidies, Alexander, Müller, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103247/ https://www.ncbi.nlm.nih.gov/pubmed/35563046 http://dx.doi.org/10.3390/ijms23094656

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