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Reverse Engineering Analysis of the High-Temperature Reversible Oligomerization and Amyloidogenicity of PSD95-PDZ3

PSD95-PDZ3, the third PDZ domain of the post-synaptic density-95 protein (MW 11 kDa), undergoes a peculiar three-state thermal denaturation (N ↔ I(n) ↔ D) and is amyloidogenic. PSD95-PDZ3 in the intermediate state (I) is reversibly oligomerized (RO: Reversible oligomerization). We previously reporte...

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Detalles Bibliográficos
Autores principales:	Onchaiya, Sawaros, Saotome, Tomonori, Mizutani, Kenji, Martinez, Jose C., Tame, Jeremy R. H., Kidokoro, Shun-ichi, Kuroda, Yutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103278/ https://www.ncbi.nlm.nih.gov/pubmed/35566161 http://dx.doi.org/10.3390/molecules27092813

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