POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition

We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD(+)/NADH ratio in both neural stem cells (NSCs) and astrocytes differentiated from induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Anbin, Kristiansen, Cecilie Katrin, Høyland, Lena Elise, Ziegler, Mathias, Wang, Jian, Sullivan, Gareth John, Li, Xingang, Bindoff, Laurence A., Liang, Kristina Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103491/
https://www.ncbi.nlm.nih.gov/pubmed/35298342
http://dx.doi.org/10.1080/15384101.2022.2044136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103491/
https://www.ncbi.nlm.nih.gov/pubmed/35298342
http://dx.doi.org/10.1080/15384101.2022.2044136

Ejemplares similares