Cargando…

Dynamic Phenomena and Complexation Effects in the α-Lithiation and Asymmetric Functionalization of Azetidines

In this work it is demonstrated that enantiomerically enriched N-alkyl 2-oxazolinylazetidines undergo exclusive α-lithiation, and that the resulting lithiated intermediate is chemically stable but configurationally labile under the given experimental conditions that afford enantioenriched N-alkyl-2,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Musci, Pantaleo, Colella, Marco, Altomare, Angela, Romanazzi, Giuseppe, Sheikh, Nadeem S., Degennaro, Leonardo, Luisi, Renzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103493/ https://www.ncbi.nlm.nih.gov/pubmed/35566200 http://dx.doi.org/10.3390/molecules27092847

Ejemplares similares

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines
por: Musci, Pantaleo, et al.
Publicado: (2019)

1,3-Dibromo-1,1-difluoro-2-propanone as a Useful Synthon for a Chemoselective Preparation of 4-Bromodifluoromethyl Thiazoles
por: Colella, Marco, et al.
Publicado: (2018)

Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles
por: Colella, Marco, et al.
Publicado: (2020)

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis
por: Fanelli, Flavio, et al.
Publicado: (2017)

Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides
por: Zenzola, Marina, et al.
Publicado: (2016)

Synthesis and Transformations of NH‐Sulfoximines
por: Andresini, Michael, et al.
Publicado: (2021)

Listerine and Lithiated Hydrangea
Publicado: (1884)

Rigid and concave, 2,4-cis-substituted azetidine derivatives: A platform for asymmetric catalysis
por: Yoshizawa, Akina, et al.
Publicado: (2018)

Multistep Continuous Flow Synthesis of Isolable NH(2)‐Sulfinamidines via Nucleophilic Addition to Transient Sulfurdiimide
por: Andresini, Michael, et al.
Publicado: (2022)

Dynamic instability of lithiated phosphorene
por: Jia, Lingchun, et al.
Publicado: (2020)

Palladium and Platinum 2,4-cis-amino Azetidine and Related Complexes
por: Yoshizawa, Akina, et al.
Publicado: (2018)

Chelation-Assisted Substrate-Controlled Asymmetric Lithiation-Allylboration of Chiral Carbamate 1,2,4-Butanetriol Acetonide
por: Mahmood, Adeem, et al.
Publicado: (2015)

1-Benzoyl-3,3-dinitroazetidine
por: Yan, Biao, et al.
Publicado: (2009)

Passerini Reactions on Biocatalytically Derived Chiral Azetidines
por: Moni, Lisa, et al.
Publicado: (2016)

Synthesis of azetidines by aza Paternò–Büchi reactions
por: Richardson, Alistair D., et al.
Publicado: (2020)

High damage tolerance of electrochemically lithiated silicon
por: Wang, Xueju, et al.
Publicado: (2015)

312 MAX Phases: Elastic Properties and Lithiation
por: Filippatos, P.P., et al.
Publicado: (2019)

Lithiating magneto-ionics in a rechargeable battery
por: Hu, Yong, et al.
Publicado: (2022)

Alkenes from β-lithiooxyphosphonium ylides generated by trapping α-lithiated terminal epoxides with triphenylphosphine
por: Hodgson, David M, et al.
Publicado: (2012)

Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
por: Giovine, Arianna, et al.
Publicado: (2014)

Synthesis of optically active 2-substituted azetidine-2-carbonitriles from chiral 1-arylethylamine via α-alkylation of N-borane complexes
por: Tayama, Eiji, et al.
Publicado: (2021)

Application of Lithiation–Borylation to the Total Synthesis of (−)-Rakicidin F
por: Bold, Christian P., et al.
Publicado: (2022)

Thick Sintered Electrode Lithium-Ion Battery Discharge Simulations: Incorporating Lithiation-Dependent Electronic Conductivity and Lithiation Gradient Due to Charge Cycle
por: Cai, Chen, et al.
Publicado: (2020)

α-Lithiation and Electrophilic Substitution of 1,4,4-Trimethyl-3,4-dihydroquinolin-2-one
por: Sébastien, Bouclé, et al.
Publicado: (2010)

Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents
por: Yan, Qi, et al.
Publicado: (2016)

Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors
por: Pérez-Faginas, Paula, et al.
Publicado: (2011)

Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines
por: Tyler, Jasper L., et al.
Publicado: (2022)

Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza-Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene)Acetates
por: Gudelis, Emilis, et al.
Publicado: (2023)

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents
por: Gau, Michael R., et al.
Publicado: (2016)

Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench
por: Carter, Nicholas, et al.
Publicado: (2017)

Rapid and reversible lithiation of doped biogenous iron oxide nanoparticles
por: Misawa, Masaaki, et al.
Publicado: (2019)

Probing Exfoliated Graphene Layers and Their Lithiation with Microfocused X-rays
por: Zielinski, Patrik, et al.
Publicado: (2019)

Electrophile-Dependent Reactivity of Lithiated N-Benzylpyrene-1-Carboxamide
por: Ciechańska, Magdalena, et al.
Publicado: (2022)

Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines
por: Das, Anjan, et al.
Publicado: (2023)

Azetidin-2-ones: structures of antimitotic compounds based on the 1-(3,4,5-trimethoxyphenyl)azetidin-2-one core
por: Twamley, Brendan, et al.
Publicado: (2020)

Short Convergent Synthesis of the Mycolactone Core Through Lithiation–Borylation Homologations
por: Brown, Christopher A., et al.
Publicado: (2015)

An Improved Synthesis of Some 5-Substituted Indolizines Using Regiospecific Lithiation
por: Kuznetsov, Alexey G., et al.
Publicado: (2005)

Pre‐Lithiation Strategies for Next‐Generation Practical Lithium‐Ion Batteries
por: Jin, Liming, et al.
Publicado: (2021)

Exploring Metastable Phases During Lithiation of Organic Battery Electrode Materials
por: Carvalho, Rodrigo P., et al.
Publicado: (2022)

Electronic signatures of Lorentzian dynamics and charge fluctuations in lithiated graphite structures
por: Jamnuch, Sasawat, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hpod96nifi5t3o287eu9ntdfjo