Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach

Schizandrol A (SZA) and schizandrol B (SZB) are two active ingredients of Wuzhi capsule (WZC), a Chinese proprietary medicine commonly prescribed to alleviate tacrolimus (FK-506)-induced hepatoxicity in China. Due to their inhibitory effects on cytochrome P450 (CYP) 3A enzymes, SZA/SZB may display d...

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Detalles Bibliográficos
Autores principales: He, Qingfeng, Bu, Fengjiao, Wang, Qizhen, Li, Min, Lin, Jiaying, Tang, Zhijia, Mak, Wen Yao, Zhuang, Xiaomei, Zhu, Xiao, Lin, Hai-Shu, Xiang, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103789/
https://www.ncbi.nlm.nih.gov/pubmed/35562875
http://dx.doi.org/10.3390/ijms23094485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103789/
https://www.ncbi.nlm.nih.gov/pubmed/35562875
http://dx.doi.org/10.3390/ijms23094485

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