Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death

Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle arrest, senescence, metabolism, and autophagy. One of the genes that p53 activates is MDM2, which forms a negative feedback l...

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Detalles Bibliográficos
Autores principales: Koo, Nayeong, Sharma, Arun K., Narayan, Satya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103871/
https://www.ncbi.nlm.nih.gov/pubmed/35563397
http://dx.doi.org/10.3390/ijms23095005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103871/
https://www.ncbi.nlm.nih.gov/pubmed/35563397
http://dx.doi.org/10.3390/ijms23095005

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