Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study

Bipolar disorder is associated with an inflammation-triggered elevated catabolism of tryptophan to the kynurenine pathway, which impacts psychiatric symptoms and outcomes. The data indicate that lithium exerts anti-inflammatory effects by inhibiting indoleamine-2,3-dioxygenase (IDO)-1 activity. This...

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Detalles Bibliográficos
Autores principales: Fellendorf, Frederike T., Manchia, Mirko, Squassina, Alessio, Pisanu, Claudia, Dall’Acqua, Stefano, Sut, Stefania, Nasini, Sofia, Congiu, Donatella, Reininghaus, Eva Z., Garzilli, Mario, Guiso, Beatrice, Suprani, Federico, Paribello, Pasquale, Pulcinelli, Vittoria, Iaselli, Maria Novella, Pinna, Ilaria, Somaini, Giulia, Arru, Laura, Corrias, Carolina, Pinna, Federica, Carpiniello, Bernardo, Comai, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103936/
https://www.ncbi.nlm.nih.gov/pubmed/35566641
http://dx.doi.org/10.3390/jcm11092517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103936/
https://www.ncbi.nlm.nih.gov/pubmed/35566641
http://dx.doi.org/10.3390/jcm11092517

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