Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset

Age is a risk factor for a host of poor outcomes following traumatic brain injury (TBI), with some evidence suggesting that age is also a source of excess disability. We tested the extent to which age moderates the effect of injury severity on functional trajectories over 15 years post injury. Data...

Descripción completa

Detalles Bibliográficos
Autores principales: Winter, Laraine, Mensinger, Janell L., Moriarty, Helene J., Robinson, Keith M., McKay, Michelle, Leiby, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104127/
https://www.ncbi.nlm.nih.gov/pubmed/35566607
http://dx.doi.org/10.3390/jcm11092477
_version_ 1784707718976634880
author Winter, Laraine
Mensinger, Janell L.
Moriarty, Helene J.
Robinson, Keith M.
McKay, Michelle
Leiby, Benjamin E.
author_facet Winter, Laraine
Mensinger, Janell L.
Moriarty, Helene J.
Robinson, Keith M.
McKay, Michelle
Leiby, Benjamin E.
author_sort Winter, Laraine
collection PubMed
description Age is a risk factor for a host of poor outcomes following traumatic brain injury (TBI), with some evidence suggesting that age is also a source of excess disability. We tested the extent to which age moderates the effect of injury severity on functional trajectories over 15 years post injury. Data from 11,442 participants from the 2020 National Institute of Disability and Independent Living Rehabiitation Research (NIDILRR) Traumatic Brain Injury Model Systems (TBIMS) National Dataset were analyzed using linear mixed effects models. Injury severity was operationally defined using a composite of Glasgow Coma Scale scores, structural imaging findings, and the number of days with post-trauma amnesia. Functioning was measured using the Glasgow Outcomes Scale-Extended. Age at injury was the hypothesized moderator. Race, ethnicity, sex, education, and marital status served as covariates. The results showed a significant confounder-adjusted effect of injury severity and age of injury on the linear slope in functioning. The age effect was strongest for those with mild TBI. Thus, the effects of injury severity on functional trajectory were found to be moderated by age. To optimize outcomes, TBI rehabilitation should be developed specifically for older patients. Age should also be a major focus in TBI research.
format Online
Article
Text
id pubmed-9104127
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91041272022-05-14 Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset Winter, Laraine Mensinger, Janell L. Moriarty, Helene J. Robinson, Keith M. McKay, Michelle Leiby, Benjamin E. J Clin Med Article Age is a risk factor for a host of poor outcomes following traumatic brain injury (TBI), with some evidence suggesting that age is also a source of excess disability. We tested the extent to which age moderates the effect of injury severity on functional trajectories over 15 years post injury. Data from 11,442 participants from the 2020 National Institute of Disability and Independent Living Rehabiitation Research (NIDILRR) Traumatic Brain Injury Model Systems (TBIMS) National Dataset were analyzed using linear mixed effects models. Injury severity was operationally defined using a composite of Glasgow Coma Scale scores, structural imaging findings, and the number of days with post-trauma amnesia. Functioning was measured using the Glasgow Outcomes Scale-Extended. Age at injury was the hypothesized moderator. Race, ethnicity, sex, education, and marital status served as covariates. The results showed a significant confounder-adjusted effect of injury severity and age of injury on the linear slope in functioning. The age effect was strongest for those with mild TBI. Thus, the effects of injury severity on functional trajectory were found to be moderated by age. To optimize outcomes, TBI rehabilitation should be developed specifically for older patients. Age should also be a major focus in TBI research. MDPI 2022-04-28 /pmc/articles/PMC9104127/ /pubmed/35566607 http://dx.doi.org/10.3390/jcm11092477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Winter, Laraine
Mensinger, Janell L.
Moriarty, Helene J.
Robinson, Keith M.
McKay, Michelle
Leiby, Benjamin E.
Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset
title Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset
title_full Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset
title_fullStr Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset
title_full_unstemmed Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset
title_short Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset
title_sort age moderates the effect of injury severity on functional trajectories in traumatic brain injury: a study using the nidilrr traumatic brain injury model systems national dataset
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104127/
https://www.ncbi.nlm.nih.gov/pubmed/35566607
http://dx.doi.org/10.3390/jcm11092477
work_keys_str_mv AT winterlaraine agemoderatestheeffectofinjuryseverityonfunctionaltrajectoriesintraumaticbraininjuryastudyusingthenidilrrtraumaticbraininjurymodelsystemsnationaldataset
AT mensingerjanelll agemoderatestheeffectofinjuryseverityonfunctionaltrajectoriesintraumaticbraininjuryastudyusingthenidilrrtraumaticbraininjurymodelsystemsnationaldataset
AT moriartyhelenej agemoderatestheeffectofinjuryseverityonfunctionaltrajectoriesintraumaticbraininjuryastudyusingthenidilrrtraumaticbraininjurymodelsystemsnationaldataset
AT robinsonkeithm agemoderatestheeffectofinjuryseverityonfunctionaltrajectoriesintraumaticbraininjuryastudyusingthenidilrrtraumaticbraininjurymodelsystemsnationaldataset
AT mckaymichelle agemoderatestheeffectofinjuryseverityonfunctionaltrajectoriesintraumaticbraininjuryastudyusingthenidilrrtraumaticbraininjurymodelsystemsnationaldataset
AT leibybenjamine agemoderatestheeffectofinjuryseverityonfunctionaltrajectoriesintraumaticbraininjuryastudyusingthenidilrrtraumaticbraininjurymodelsystemsnationaldataset