Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice

Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice universally over-expressing human estrogen biosynthetic enzyme HS...

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Detalles Bibliográficos
Autores principales: Heinosalo, Taija, Rytkönen, Kalle T., Saarinen, Niina, Järvensivu, Päivi, Damdimopoulou, Pauliina, Strauss, Leena, Orasniemi, Satu, Horshauge, Petricia, Gabriel, Michael, Koskimies, Pasi, Ohlsson, Claes, Kronqvist, Pauliina, Poutanen, Matti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104619/
https://www.ncbi.nlm.nih.gov/pubmed/35563206
http://dx.doi.org/10.3390/ijms23094815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104619/
https://www.ncbi.nlm.nih.gov/pubmed/35563206
http://dx.doi.org/10.3390/ijms23094815

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