A general calculus of fitness landscapes finds genes under selection in cancers

Genetic variants drive the evolution of traits and diseases. We previously modeled these variants as small displacements in fitness landscapes and estimated their functional impact by differentiating the evolutionary relationship between genotype and phenotype. Conversely, here we integrate these de...

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Detalles Bibliográficos
Autores principales: Hsu, Teng-Kuei, Asmussen, Jennifer, Koire, Amanda, Choi, Byung-Kwon, Gadhikar, Mayur A., Huh, Eunna, Lin, Chih-Hsu, Konecki, Daniel M., Kim, Young Won, Pickering, Curtis R., Kimmel, Marek, Donehower, Lawrence A., Frederick, Mitchell J., Myers, Jeffrey N., Katsonis, Panagiotis, Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104707/
https://www.ncbi.nlm.nih.gov/pubmed/35301263
http://dx.doi.org/10.1101/gr.275811.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104707/
https://www.ncbi.nlm.nih.gov/pubmed/35301263
http://dx.doi.org/10.1101/gr.275811.121

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