Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo

The orphan nuclear receptor 4A1 (NR4A1) is highly expressed in human pancreatic cancer cells and exerts pro-oncogenic activity. In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hyo-Seon, Kim, Dae Hwan, Lee, In-Seon, Park, Ji-Hyun, Martin, Gregory, Safe, Stephen, Kim, Keuk-Jun, Kim, Joung-Hee, Jang, Byung Ik, Lee, Syng-Ook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104798/
https://www.ncbi.nlm.nih.gov/pubmed/35563670
http://dx.doi.org/10.3390/ijms23095280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104798/
https://www.ncbi.nlm.nih.gov/pubmed/35563670
http://dx.doi.org/10.3390/ijms23095280

Ejemplares similares