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Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo

The orphan nuclear receptor 4A1 (NR4A1) is highly expressed in human pancreatic cancer cells and exerts pro-oncogenic activity. In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells. In...

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Detalles Bibliográficos
Autores principales:	Lee, Hyo-Seon, Kim, Dae Hwan, Lee, In-Seon, Park, Ji-Hyun, Martin, Gregory, Safe, Stephen, Kim, Keuk-Jun, Kim, Joung-Hee, Jang, Byung Ik, Lee, Syng-Ook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104798/ https://www.ncbi.nlm.nih.gov/pubmed/35563670 http://dx.doi.org/10.3390/ijms23095280

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