Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity

Reverse transcriptase hTERT is essential to telomerase function in stem cells, as well as in 85–90% of human cancers. Its high expression in stem cells or cancer cells has made telomerase/hTERT an attractive therapeutic target for anti-aging and anti-tumor applications. In this study, we screened a...

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Detalles Bibliográficos
Autores principales: Yan, Siyu, Lin, Song, Chen, Kexin, Yin, Shanshan, Peng, Haoyue, Cai, Nanshuo, Ma, Wenbin, Songyang, Zhou, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104802/
https://www.ncbi.nlm.nih.gov/pubmed/35563795
http://dx.doi.org/10.3390/cells11091485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104802/
https://www.ncbi.nlm.nih.gov/pubmed/35563795
http://dx.doi.org/10.3390/cells11091485

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