Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase

A reactive metabolite of nonsteroidal anti-inflammatory drugs (NSAIDs), acyl-β-D-glucuronide (AG), covalently binds to endogenous proteins. The covalent adduct formation of NSAIDs-AG may lead to the dysfunction of target proteins. Therefore, it is important to clarify the detailed characterization o...

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Detalles Bibliográficos
Autores principales: Kawase, Atsushi, Yamashita, Rio, Yoshizato, Tsubasa, Yoshikawa, Mashiro, Shimada, Hiroaki, Iwaki, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104950/
https://www.ncbi.nlm.nih.gov/pubmed/35563116
http://dx.doi.org/10.3390/ijms23094724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104950/
https://www.ncbi.nlm.nih.gov/pubmed/35563116
http://dx.doi.org/10.3390/ijms23094724

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