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Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase

A reactive metabolite of nonsteroidal anti-inflammatory drugs (NSAIDs), acyl-β-D-glucuronide (AG), covalently binds to endogenous proteins. The covalent adduct formation of NSAIDs-AG may lead to the dysfunction of target proteins. Therefore, it is important to clarify the detailed characterization o...

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Detalles Bibliográficos
Autores principales:	Kawase, Atsushi, Yamashita, Rio, Yoshizato, Tsubasa, Yoshikawa, Mashiro, Shimada, Hiroaki, Iwaki, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104950/ https://www.ncbi.nlm.nih.gov/pubmed/35563116 http://dx.doi.org/10.3390/ijms23094724

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