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Urine-Derived Stem Cell-Secreted Klotho Plays a Crucial Role in the HK-2 Fibrosis Model by Inhibiting the TGF-β Signaling Pathway

Renal fibrosis is an irreversible and progressive process that causes severe dysfunction in chronic kidney disease (CKD). The progression of CKD stages is highly associated with a gradual reduction in serum Klotho levels. We focused on Klotho protein as a key therapeutic factor against CKD. Urine-de...

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Detalles Bibliográficos
Autores principales: Kim, Sang-Heon, Jin, Jeong-Ah, So, Hyung Joon, Lee, Sung Hoon, Kang, Tae-Wook, Lee, Jae-Ung, Choi, Dae Eun, Jeong, Jin Young, Chang, Yoon-Kyung, Choi, Hyunsu, Lee, Youngjun, Seo, Young-Kwon, Lee, Hong-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105028/
https://www.ncbi.nlm.nih.gov/pubmed/35563402
http://dx.doi.org/10.3390/ijms23095012