Antiinflammation Derived Suzuki-Coupled Fenbufens as COX-2 Inhibitors: Minilibrary Construction and Bioassay

A small fenbufen library comprising 18 compounds was prepared via Suzuki Miyara coupling. The five-step preparations deliver 9–17% biphenyl compounds in total yield. These fenbufen analogs exert insignificant activity against the IL-1 release as well as inhibiting cyclooxygenase 2 considerably. Both...

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Detalles Bibliográficos
Autores principales: Farn, Shiou-Shiow, Lai, Yen-Buo, Hua, Kuo-Fong, Chen, Hsiang-Ping, Yu, Tzu-Yi, Lo, Sheng-Nan, Shen, Li-Hsin, Sheu, Rong-Jiun, Yu, Chung-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105197/
https://www.ncbi.nlm.nih.gov/pubmed/35566202
http://dx.doi.org/10.3390/molecules27092850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105197/
https://www.ncbi.nlm.nih.gov/pubmed/35566202
http://dx.doi.org/10.3390/molecules27092850

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