Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a dele...

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Detalles Bibliográficos
Autores principales: Kouranti, Ilektra, Abdel Khalek, Waed, Mazurkiewicz, Stephani, Loisel-Ferreira, Irmine, Gautreau, Alexis M., Pintard, Lionel, Jeunemaitre, Xavier, Clauser, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105235/
https://www.ncbi.nlm.nih.gov/pubmed/35563538
http://dx.doi.org/10.3390/ijms23095151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105235/
https://www.ncbi.nlm.nih.gov/pubmed/35563538
http://dx.doi.org/10.3390/ijms23095151

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