Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1

Oligophrenin-1 (OPHN1) is a Rho-GTPase-activating protein (RhoGAP), whose mutations are associated with X-linked intellectual disability (XLID). OPHN1 is enriched at the synapse in both pre- and postsynaptic compartments, where it regulates the RhoA/ROCK/MLC2 signaling pathway, playing a critical ro...

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Detalles Bibliográficos
Autores principales: Cresto, Noemie, Lebrun, Nicolas, Dumont, Florent, Letourneur, Franck, Billuart, Pierre, Rouach, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105236/
https://www.ncbi.nlm.nih.gov/pubmed/35563851
http://dx.doi.org/10.3390/cells11091545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105236/
https://www.ncbi.nlm.nih.gov/pubmed/35563851
http://dx.doi.org/10.3390/cells11091545

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