Specific Amino Acid Substitutions in OXA-51-Type β-Lactamase Enhance Catalytic Activity to a Level Comparable to Carbapenemase OXA-23 and OXA-24/40

The chromosomal bla(OXA-51)-type gene encodes carbapenem-hydrolyzing class D β-lactamases (CHDLs), specific variants shown to mediate carbapenem resistance in the Gram-negative bacterial pathogen Acinetobacter baumannii. This study aims to characterize the effect of key amino acid substitutions in O...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Kwan-Wai, Liu, Chen-Yu, Wong, Ho-Yin, Chan, Wai-Chi, Wong, Kwok-Yin, Chen, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105447/
https://www.ncbi.nlm.nih.gov/pubmed/35562886
http://dx.doi.org/10.3390/ijms23094496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105447/
https://www.ncbi.nlm.nih.gov/pubmed/35562886
http://dx.doi.org/10.3390/ijms23094496

Ejemplares similares