Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas

SIMPLE SUMMARY: Three different murine glioma cell lines were modified to downregulate expression of the murine LDH-A gene using shRNA knockdown (KD) and compared to pharmacologic (GNE-R-140) inhibition of the LDH enzyme complex, and to shRNA scrambled control (NC) cell lines. The effects of shRNA L...

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Detalles Bibliográficos
Autores principales: Maeda, Masatomo, Ko, Myat, Mane, Mayuresh M., Cohen, Ivan J., Shindo, Masahiro, Vemuri, Kiranmayi, Serganova, Inna, Blasberg, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105502/
https://www.ncbi.nlm.nih.gov/pubmed/35565435
http://dx.doi.org/10.3390/cancers14092306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105502/
https://www.ncbi.nlm.nih.gov/pubmed/35565435
http://dx.doi.org/10.3390/cancers14092306

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