ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine Dependency

Previously, the in vitro growth of cancer stem cells in the form of tumor spheres from five different brain cancer cell lines was found to be methionine-dependent. As this earlier work indicated that ALDH1L2, a folate-dependent mitochondria aldehyde dehydrogenase gene, is upregulated in glioblastoma...

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Detalles Bibliográficos
Autores principales: Quéré, Maëlle, Alberto, Jean-Marc, Broly, Franck, Hergalant, Sébastien, Christov, Christo, Gauchotte, Guillaume, Guéant, Jean-Louis, Namour, Farès, Battaglia-Hsu, Shyue-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105572/
https://www.ncbi.nlm.nih.gov/pubmed/35565854
http://dx.doi.org/10.3390/nu14091887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105572/
https://www.ncbi.nlm.nih.gov/pubmed/35565854
http://dx.doi.org/10.3390/nu14091887

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