Modulating Nucleus Oxygen Concentration by Altering Intramembrane Cholesterol Levels: Creating Hypoxic Nucleus in Oxic Conditions

We propose a novel mechanism by which cancer cells can modulate the oxygen concentration within the nucleus, potentially creating low nuclear oxygen conditions without the need of an hypoxic micro-environment and suited for allowing cancer cells to resist chemo- and radio-therapy. The cells ability...

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Detalles Bibliográficos
Autores principales: Seco, Joao, King, Clarence C., Camazzola, Gianmarco, Jansen, Jeannette, Tirinato, Luca, Marafioti, Maria G., Hanley, Rachel, Pagliari, Francesca, Beckman, Scott P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105739/
https://www.ncbi.nlm.nih.gov/pubmed/35563465
http://dx.doi.org/10.3390/ijms23095077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105739/
https://www.ncbi.nlm.nih.gov/pubmed/35563465
http://dx.doi.org/10.3390/ijms23095077

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