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Modulating Nucleus Oxygen Concentration by Altering Intramembrane Cholesterol Levels: Creating Hypoxic Nucleus in Oxic Conditions

We propose a novel mechanism by which cancer cells can modulate the oxygen concentration within the nucleus, potentially creating low nuclear oxygen conditions without the need of an hypoxic micro-environment and suited for allowing cancer cells to resist chemo- and radio-therapy. The cells ability...

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Detalles Bibliográficos
Autores principales:	Seco, Joao, King, Clarence C., Camazzola, Gianmarco, Jansen, Jeannette, Tirinato, Luca, Marafioti, Maria G., Hanley, Rachel, Pagliari, Francesca, Beckman, Scott P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105739/ https://www.ncbi.nlm.nih.gov/pubmed/35563465 http://dx.doi.org/10.3390/ijms23095077

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