Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma

SIMPLE SUMMARY: Membrane-associated PCNA is expressed on the surface of human MM cell lines and primary MM cells. Mab 14-25-9 interacts with membrane-associated PCNA and blocks its binding to NK-expressed NKp44, thus activating NK function. We showed that mAb 14-25-9 can serve as an immune checkpoin...

Descripción completa

Detalles Bibliográficos
Autores principales: Iraqi, Muhammed, Edri, Avishay, Greenshpan, Yariv, Goldstein, Oron, Ofir, Noa, Bolel, Priyanka, Abu Ahmad, Muhammad, Zektser, Miri, Campbell, Kerry S., Rouvio, Ory, Gazit, Roi, Porgador, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105815/
https://www.ncbi.nlm.nih.gov/pubmed/35563109
http://dx.doi.org/10.3390/ijms23094717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105815/
https://www.ncbi.nlm.nih.gov/pubmed/35563109
http://dx.doi.org/10.3390/ijms23094717

Ejemplares similares