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Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma
SIMPLE SUMMARY: Membrane-associated PCNA is expressed on the surface of human MM cell lines and primary MM cells. Mab 14-25-9 interacts with membrane-associated PCNA and blocks its binding to NK-expressed NKp44, thus activating NK function. We showed that mAb 14-25-9 can serve as an immune checkpoin...
Autores principales: | Iraqi, Muhammed, Edri, Avishay, Greenshpan, Yariv, Goldstein, Oron, Ofir, Noa, Bolel, Priyanka, Abu Ahmad, Muhammad, Zektser, Miri, Campbell, Kerry S., Rouvio, Ory, Gazit, Roi, Porgador, Angel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105815/ https://www.ncbi.nlm.nih.gov/pubmed/35563109 http://dx.doi.org/10.3390/ijms23094717 |
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