Cargando…

The Regulatory Roles of Intrinsically Disordered Linker in VRN1-DNA Phase Separation

Biomacromolecules often form condensates to function in cells. VRN1 is a transcriptional repressor that plays a key role in plant vernalization. Containing two DNA-binding domains connected by an intrinsically disordered linker (IDL), VRN1 was shown to undergo liquid-like phase separation with DNA,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Qiaojing, Wang, Yanyan, Liu, Zhirong, Lai, Luhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106000/ https://www.ncbi.nlm.nih.gov/pubmed/35562982 http://dx.doi.org/10.3390/ijms23094594

Ejemplares similares

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
por: Harmon, Tyler S, et al.
Publicado: (2017)

Small molecules in regulating protein phase separation: Regulating protein phase separation by small molecules
por: Li, Siyang, et al.
Publicado: (2023)

Correlation of Vernalization Loci VRN-H1 and VRN-H2 and Growth Habit in Barley Germplasm
por: Mohammadi, Mohsen, et al.
Publicado: (2013)

Ligand Clouds around Protein Clouds: A Scenario of Ligand Binding with Intrinsically Disordered Proteins
por: Jin, Fan, et al.
Publicado: (2013)

Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc
por: Yu, Chen, et al.
Publicado: (2016)

Wheat TILLING Mutants Show That the Vernalization Gene VRN1 Down-Regulates the Flowering Repressor VRN2 in Leaves but Is Not Essential for Flowering
por: Chen, Andrew, et al.
Publicado: (2012)

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization
por: Gemeinhardt, Tim M., et al.
Publicado: (2023)

Are the intrinsically disordered linkers involved in SSB binding to accessory proteins?
por: Shinn, Min Kyung, et al.
Publicado: (2019)

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP
por: Contreras-Martos, Sara, et al.
Publicado: (2017)

Allele frequencies in the VRN-A1, VRN-B1 and VRN-D1 vernalization response and PPD-B1 and PPD-D1 photoperiod sensitivity genes, and their effects on heading in a diverse set of wheat cultivars (Triticum aestivum L.)
por: Kiss, Tibor, et al.
Publicado: (2014)

In-Depth Sequence Analysis of Bread Wheat VRN1 Genes
por: Strejčková, Beáta, et al.
Publicado: (2021)

An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook
por: Barker, Clive S., et al.
Publicado: (2017)

Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs
por: Chiu, Shih-Hui, et al.
Publicado: (2022)

The Role of Intrinsically Disordered Proteins in Liquid–Liquid Phase Separation during Calcium Carbonate Biomineralization
por: Tarczewska, Aneta, et al.
Publicado: (2022)

Molecular characterization of vernalization loci VRN1 in wild and cultivated wheats
por: Golovnina, Kseniya A, et al.
Publicado: (2010)

Evolution of VRN-1 homoeologous loci in allopolyploids of Triticum and their diploid precursors
por: Shcherban, Andrey B., et al.
Publicado: (2017)

Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
por: Guillen-Chable, Francisco, et al.
Publicado: (2021)

Determinants for intrinsically disordered protein recruitment into phase-separated protein condensates
por: Jo, Yongsang, et al.
Publicado: (2021)

Uncharged Components of Single-Stranded DNA Modulate Liquid–Liquid Phase Separation With Cationic Linker Histone H1
por: Mimura, Masahiro, et al.
Publicado: (2021)

Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains
por: Szabo, Beata, et al.
Publicado: (2019)

Association of the Recessive Allele vrn-D1 With Winter Frost Tolerance in Bread Wheat
por: Zhang, Hongjun, et al.
Publicado: (2022)

Relevance of Electrostatic Charges in Compactness, Aggregation, and Phase Separation of Intrinsically Disordered Proteins
por: Bianchi, Greta, et al.
Publicado: (2020)

Intrinsically disordered proteins access a range of hysteretic phase separation behaviors
por: Garcia Quiroz, Felipe, et al.
Publicado: (2019)

Phase separation propensity of the intrinsically disordered AB region of human RXRβ
por: Sołtys, Katarzyna, et al.
Publicado: (2023)

Liquid–Liquid Phase Separation Modifies the Dynamic Properties of Intrinsically Disordered Proteins
por: Guseva, Serafima, et al.
Publicado: (2023)

Characterization of the maintained vegetative phase deletions from diploid wheat and their effect on VRN2 and FT transcript levels
por: Distelfeld, Assaf, et al.
Publicado: (2010)

Single nucleotide polymorphisms in a regulatory site of VRN-A1 first intron are associated with differences in vernalization requirement in winter wheat
por: Kippes, Nestor, et al.
Publicado: (2018)

A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation
por: Dettori, Leonardo G., et al.
Publicado: (2021)

VRN1 genes variability in tetraploid wheat species with a spring growth habit
por: Konopatskaia, Irina, et al.
Publicado: (2016)

Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid–Liquid Phase Separation
por: Garaizar, Adiran, et al.
Publicado: (2020)

Effects of linker length on phase separation: lessons from the Rubisco-EPYC1 system of the algal pyrenoid
por: GrandPre, Trevor, et al.
Publicado: (2023)

The juxtamembrane linker of synaptotagmin 1 regulates Ca(2+) binding via liquid-liquid phase separation
por: Mehta, Nikunj, et al.
Publicado: (2023)

The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading
por: Schweibenz, Brandon D, et al.
Publicado: (2022)

Wheat VRN1, FUL2 and FUL3 play critical and redundant roles in spikelet development and spike determinacy
por: Li, Chengxia, et al.
Publicado: (2019)

Vernalization treatment induces site-specific DNA hypermethylation at the VERNALIZATION-A1 (VRN-A1) locus in hexaploid winter wheat
por: Khan, Abdul Rehman, et al.
Publicado: (2013)

The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction
por: Sundararajan, Kousik, et al.
Publicado: (2015)

Vernalization requirement duration in winter wheat is controlled by TaVRN-A1 at the protein level
por: Li, Genqiao, et al.
Publicado: (2013)

A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs
por: Oh, Zhen Guo, et al.
Publicado: (2023)

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
por: Lin, Yuan, et al.
Publicado: (2017)

Thermodynamic and sequential characteristics of phase separation and droplet formation for an intrinsically disordered region/protein ensemble
por: Chu, Wen-Ting, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m38sclfj66rl9b23c08bj5b7d5