Design, Synthesis and Biological Evaluation of N-phenylindole Derivatives as Pks13 Inhibitors againstMycobacterium tuberculosis

Polyketide synthase 13 (Pks13), an essential enzyme for the survival of Mycobacterium tuberculosis (Mtb), is an attractive target for new anti-TB agents. In our previous work, we have identified 2-phenylindole derivatives against Mtb. The crystallography studies demonstrated that the two-position ph...

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Detalles Bibliográficos
Autores principales: Cai, Yanpeng, Zhang, Wei, Lun, Shichun, Zhu, Tongtong, Xu, Weijun, Yang, Fan, Tang, Jie, Bishai, William R., Yu, Lifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106008/
https://www.ncbi.nlm.nih.gov/pubmed/35566191
http://dx.doi.org/10.3390/molecules27092844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106008/
https://www.ncbi.nlm.nih.gov/pubmed/35566191
http://dx.doi.org/10.3390/molecules27092844

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