Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited

The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH). This electron transfer supports Complexes CIII and CIV, thus generating the protonmotive force. Further catabolism of P5C forms gluta...

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Detalles Bibliográficos
Autores principales: Pallag, Gergely, Nazarian, Sara, Ravasz, Dora, Bui, David, Komlódi, Timea, Doerrier, Carolina, Gnaiger, Erich, Seyfried, Thomas N., Chinopoulos, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106064/
https://www.ncbi.nlm.nih.gov/pubmed/35563503
http://dx.doi.org/10.3390/ijms23095111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106064/
https://www.ncbi.nlm.nih.gov/pubmed/35563503
http://dx.doi.org/10.3390/ijms23095111

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