FasL microgels induce immune acceptance of islet allografts in nonhuman primates

Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for maintenance immunosuppression. We report a strategy through which cotransplantation of allogeneic islets and streptavidin (SA)–FasL–presenting microgels to the omentum under transient rapamycin monotherapy r...

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Detalles Bibliográficos
Autores principales: Lei, Ji, Coronel, María M., Yolcu, Esma S., Deng, Hongping, Grimany-Nuno, Orlando, Hunckler, Michael D., Ulker, Vahap, Yang, Zhihong, Lee, Kang M., Zhang, Alexander, Luo, Hao, Peters, Cole W., Zou, Zhongliang, Chen, Tao, Wang, Zhenjuan, McCoy, Colleen S., Rosales, Ivy A., Markmann, James F., Shirwan, Haval, García, Andrés J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106299/
https://www.ncbi.nlm.nih.gov/pubmed/35559682
http://dx.doi.org/10.1126/sciadv.abm9881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106299/
https://www.ncbi.nlm.nih.gov/pubmed/35559682
http://dx.doi.org/10.1126/sciadv.abm9881

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