Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Exploiting cancer vulnerabilities is critical for the discovery of anticancer drugs. However, tumor suppressors cannot be directly targeted because of their loss of function. To uncover specific vulnerabilities for cells with deficiency in any given tumor suppressor(s), we performed genome-scale CRI...

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Detalles Bibliográficos
Autores principales: Feng, Xu, Tang, Mengfan, Dede, Merve, Su, Dan, Pei, Guangsheng, Jiang, Dadi, Wang, Chao, Chen, Zhen, Li, Mi, Nie, Litong, Xiong, Yun, Li, Siting, Park, Jeong-Min, Zhang, Huimin, Huang, Min, Szymonowicz, Klaudia, Zhao, Zhongming, Hart, Traver, Chen, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106303/
https://www.ncbi.nlm.nih.gov/pubmed/35559673
http://dx.doi.org/10.1126/sciadv.abm6638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106303/
https://www.ncbi.nlm.nih.gov/pubmed/35559673
http://dx.doi.org/10.1126/sciadv.abm6638

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