Rapamycin limits CD4(+) T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy

Proliferation of latently infected CD4(+) T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mTOR, a regulatory kinase involved with cell growt...

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Detalles Bibliográficos
Autores principales: Varco-Merth, Benjamin D., Brantley, William, Marenco, Alejandra, Duell, Derick D., Fachko, Devin N., Richardson, Brian, Busman-Sahay, Kathleen, Shao, Danica, Flores, Walter, Engelman, Kathleen, Fukazawa, Yoshinori, Wong, Scott W., Skalsky, Rebecca L., Smedley, Jeremy, Axthelm, Michael K., Lifson, Jeffrey D., Estes, Jacob D., Edlefsen, Paul T., Picker, Louis J., Cameron, Cheryl M.A., Henrich, Timothy J., Okoye, Afam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106346/
https://www.ncbi.nlm.nih.gov/pubmed/35316218
http://dx.doi.org/10.1172/JCI156063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106346/
https://www.ncbi.nlm.nih.gov/pubmed/35316218
http://dx.doi.org/10.1172/JCI156063

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