Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts

In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for the switch are poorly understood. We found that inhibitory factor...

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Detalles Bibliográficos
Autores principales: Zhou, Bo, Caudal, Arianne, Tang, Xiaoting, Chavez, Juan D., McMillen, Timothy S., Keller, Andrew, Villet, Outi, Zhao, Mingyue, Liu, Yaxin, Ritterhoff, Julia, Wang, Pei, Kolwicz, Stephen C., Wang, Wang, Bruce, James E., Tian, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106352/
https://www.ncbi.nlm.nih.gov/pubmed/35575090
http://dx.doi.org/10.1172/JCI155333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106352/
https://www.ncbi.nlm.nih.gov/pubmed/35575090
http://dx.doi.org/10.1172/JCI155333

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