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Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for the switch are poorly understood. We found that inhibitory factor...
Autores principales: | Zhou, Bo, Caudal, Arianne, Tang, Xiaoting, Chavez, Juan D., McMillen, Timothy S., Keller, Andrew, Villet, Outi, Zhao, Mingyue, Liu, Yaxin, Ritterhoff, Julia, Wang, Pei, Kolwicz, Stephen C., Wang, Wang, Bruce, James E., Tian, Rong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106352/ https://www.ncbi.nlm.nih.gov/pubmed/35575090 http://dx.doi.org/10.1172/JCI155333 |
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