A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants

BACKGROUND: The Delta and Omicron variants of SARS-CoV-2 are currently responsible for breakthrough infections due to waning immunity. We report phase I/II trial results of UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein and rationally designed promiscuous peptides representing sar...

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Detalles Bibliográficos
Autores principales: Wang, Chang Yi, Hwang, Kao-Pin, Kuo, Hui-Kai, Peng, Wen-Jiun, Shen, Yea-Huei, Kuo, Be-Sheng, Huang, Juin-Hua, Liu, Hope, Ho, Yu-Hsin, Lin, Feng, Ding, Shuang, Liu, Zhi, Wu, Huan-Ting, Huang, Ching-Tai, Lee, Yuarn-Jang, Liu, Ming-Che, Yang, Yi-Ching, Lu, Po-Liang, Tsai, Hung-Chin, Lee, Chen-Hsiang, Shi, Zhi-Yuan, Liu, Chun-Eng, Liao, Chun-Hsing, Chang, Feng-Yee, Chen, Hsiang-Cheng, Wang, Fu-Der, Hou, Kuo-Liang, Cheng, Jennifer, Wang, Min-Sheng, Yang, Ya-Ting, Chiu, Han-Chen, Jiang, Ming-Han, Shih, Hao-Yu, Shen, Hsuan-Yu, Chang, Po-Yen, Lan, Yu-Rou, Chen, Chi-Tian, Lin, Yi-Ling, Liang, Jian-Jong, Liao, Chun-Che, Chou, Yu-Chi, Morris, Mary Kate, Hanson, Carl V., Guirakhoo, Farshad, Hellerstein, Michael, Yu, Hui-Jing, King, Chwan-Chuen, Kemp, Tracy, Heppner, D. Gray, Monath, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106357/
https://www.ncbi.nlm.nih.gov/pubmed/35316221
http://dx.doi.org/10.1172/JCI157707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106357/
https://www.ncbi.nlm.nih.gov/pubmed/35316221
http://dx.doi.org/10.1172/JCI157707

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