Aerobic exercise elicits clinical adaptations in myotonic dystrophy type 1 patients independently of pathophysiological changes

BACKGROUND: Myotonic dystrophy type 1 (DM1) is a complex life-limiting neuromuscular disorder characterized by severe skeletal muscle atrophy, weakness, and cardiorespiratory defects. Exercised DM1 mice exhibit numerous physiological benefits that are underpinned by reduced CUG foci and improved alt...

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Detalles Bibliográficos
Autores principales: Mikhail, Andrew I., Nagy, Peter L., Manta, Katherine, Rouse, Nicholas, Manta, Alexander, Ng, Sean Y., Nagy, Michael F., Smith, Paul, Lu, Jian-Qiang, Nederveen, Joshua P., Ljubicic, Vladimir, Tarnopolsky, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106360/
https://www.ncbi.nlm.nih.gov/pubmed/35316212
http://dx.doi.org/10.1172/JCI156125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106360/
https://www.ncbi.nlm.nih.gov/pubmed/35316212
http://dx.doi.org/10.1172/JCI156125

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