Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart

Pericytes (PCs) are abundant yet remain the most enigmatic and ill-defined cell population in the heart. Here, we investigated whether PCs can be reprogrammed to aid neovascularization. Primary PCs from human and mouse hearts acquired cytoskeletal proteins typical of vascular smooth muscle cells (VS...

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Detalles Bibliográficos
Autores principales: Avolio, Elisa, Katare, Rajesh, Thomas, Anita C., Caporali, Andrea, Schwenke, Daryl, Carrabba, Michele, Meloni, Marco, Caputo, Massimo, Madeddu, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106362/
https://www.ncbi.nlm.nih.gov/pubmed/35349488
http://dx.doi.org/10.1172/JCI152308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106362/
https://www.ncbi.nlm.nih.gov/pubmed/35349488
http://dx.doi.org/10.1172/JCI152308

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