Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue. Here we provide evidence that these distinct functions are conducted by the transcription factor SOX2, which adopts different modes of chrom...

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Detalles Bibliográficos
Autores principales: Blassberg, Robert, Patel, Harshil, Watson, Thomas, Gouti, Mina, Metzis, Vicki, Delás, M. Joaquina, Briscoe, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106585/
https://www.ncbi.nlm.nih.gov/pubmed/35550614
http://dx.doi.org/10.1038/s41556-022-00910-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106585/
https://www.ncbi.nlm.nih.gov/pubmed/35550614
http://dx.doi.org/10.1038/s41556-022-00910-2

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