Efficacy and Safety of Tramadol Hydrochloride Twice-Daily Sustained-Release Bilayer Tablets with an Immediate-Release Component for Chronic Pain Associated with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study

BACKGROUND AND OBJECTIVES: Knee osteoarthritis pain is a chronic form of pain for which conventional non-steroidal anti-inflammatory drugs may provide insufficient analgesia. Twice-daily tramadol hydrochloride (65% sustained-release/35% immediate-release) bilayer tablets are a novel formulation of t...

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Detalles Bibliográficos
Autores principales: Kawai, Shinichi, Sobajima, Satoshi, Jinnouchi, Masashi, Nakano, Hideshi, Ohtani, Hideaki, Sakata, Mineo, Adachi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106645/
https://www.ncbi.nlm.nih.gov/pubmed/35435639
http://dx.doi.org/10.1007/s40261-022-01139-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106645/
https://www.ncbi.nlm.nih.gov/pubmed/35435639
http://dx.doi.org/10.1007/s40261-022-01139-5

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