Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens

Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically characterized to reveal the mechanism of TMP resistance and to support phylogenic groupings for drug development aga...

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Detalles Bibliográficos
Autores principales: Krucinska, Jolanta, Lombardo, Michael N., Erlandsen, Heidi, Estrada, Alexavier, Si, Debjani, Viswanathan, Kishore, Wright, Dennis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106665/
https://www.ncbi.nlm.nih.gov/pubmed/35562546
http://dx.doi.org/10.1038/s42003-022-03384-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106665/
https://www.ncbi.nlm.nih.gov/pubmed/35562546
http://dx.doi.org/10.1038/s42003-022-03384-y

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