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Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens
Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically characterized to reveal the mechanism of TMP resistance and to support phylogenic groupings for drug development aga...
Autores principales: | Krucinska, Jolanta, Lombardo, Michael N., Erlandsen, Heidi, Estrada, Alexavier, Si, Debjani, Viswanathan, Kishore, Wright, Dennis L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106665/ https://www.ncbi.nlm.nih.gov/pubmed/35562546 http://dx.doi.org/10.1038/s42003-022-03384-y |
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