Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3

Many synaptic proteins form biological condensates via liquid-liquid phase separation (LLPS). Synaptopathy, a key feature of autism spectrum disorders (ASD), is likely relevant to the impaired phase separation and/or transition of ASD-linked synaptic proteins. Here, we report that LLPS and zinc-indu...

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Detalles Bibliográficos
Autores principales: Shih, Pu-Yun, Fang, Yu-Lun, Shankar, Sahana, Lee, Sue-Ping, Hu, Hsiao-Tang, Chen, Hsin, Wang, Ting-Fang, Hsia, Kuo-Chiang, Hsueh, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106668/
https://www.ncbi.nlm.nih.gov/pubmed/35562389
http://dx.doi.org/10.1038/s41467-022-30353-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106668/
https://www.ncbi.nlm.nih.gov/pubmed/35562389
http://dx.doi.org/10.1038/s41467-022-30353-0

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