Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures

Each prion strain has its own characteristics and the efficacy of anti-prion drugs varies. Screening of prion disease therapeutics is typically evaluated by measuring amounts of protease-resistant prion protein (PrP-res). However, it remains unclear whether such measurements correlate with seeding a...

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Detalles Bibliográficos
Autores principales: Takatsuki, Hanae, Imamura, Morikazu, Mori, Tsuyoshi, Atarashi, Ryuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106670/
https://www.ncbi.nlm.nih.gov/pubmed/35562591
http://dx.doi.org/10.1038/s41598-022-12049-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106670/
https://www.ncbi.nlm.nih.gov/pubmed/35562591
http://dx.doi.org/10.1038/s41598-022-12049-z

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