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Cryo-EM structure of human glucose transporter GLUT4
GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization of GLUT4 is associated with diabetes. Here, we report the cryo-EM structures of human GLUT4 bound to a small mol...
Autores principales: | Yuan, Yafei, Kong, Fang, Xu, Hanwen, Zhu, Angqi, Yan, Nieng, Yan, Chuangye |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106701/ https://www.ncbi.nlm.nih.gov/pubmed/35562357 http://dx.doi.org/10.1038/s41467-022-30235-5 |
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