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Nuclear oligo hashing improves differential analysis of single-cell RNA-seq

Single-cell RNA sequencing (scRNA-seq) offers a high-resolution molecular view into complex tissues, but suffers from high levels of technical noise which frustrates efforts to compare the gene expression programs of different cell types. “Spike-in” RNA standards help control for technical variation...

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Detalles Bibliográficos
Autores principales: Kim, Hyeon-Jin, Booth, Greg, Saunders, Lauren, Srivatsan, Sanjay, McFaline-Figueroa, José L., Trapnell, Cole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106741/
https://www.ncbi.nlm.nih.gov/pubmed/35562344
http://dx.doi.org/10.1038/s41467-022-30309-4