SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

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Although mRNA vaccine efficacy against severe COVID-19 remains high, variant emergence has prompted booster immunizations. However, repeated antigen exposure effects on SARS-CoV-2 memory T cells are poorly understood. Here, we utilize MHC-multimers with scRNAseq to profile SARS-CoV-2-responsive T ce...

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Detalles Bibliográficos
Autores principales: Minervina, Anastasia A., Pogorelyy, Mikhail V., Kirk, Allison M., Crawford, Jeremy Chase, Allen, E. Kaitlynn, Chou, Ching-Heng, Mettelman, Robert C., Allison, Kim J., Lin, Chun-Yang, Brice, David C., Zhu, Xun, Vegesana, Kasi, Wu, Gang, Trivedi, Sanchit, Kottapalli, Pratibha, Darnell, Daniel, McNeely, Suzanne, Olsen, Scott R., Schultz-Cherry, Stacey, Estepp, Jeremie H., McGargill, Maureen A., Wolf, Joshua, Thomas, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106845/
https://www.ncbi.nlm.nih.gov/pubmed/35383307
http://dx.doi.org/10.1038/s41590-022-01184-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106845/
https://www.ncbi.nlm.nih.gov/pubmed/35383307
http://dx.doi.org/10.1038/s41590-022-01184-4

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