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Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease

Trypsin is a protease-activated receptor-2 (PAR2) activator that upregulates the interleukin (IL)-17 receptor signal in the airway epithelial cells and amplifies the inflammatory response, but does not modify the growth kinetics of the metapneumovirus. How does the coronavirus spread from cell to ce...

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Detalles Bibliográficos
Autores principales: Chen, Hongyu, Huang, Shirong, Chen, Qingquan, Liu, Qicai, Lv, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107181/
https://www.ncbi.nlm.nih.gov/pubmed/35580821
http://dx.doi.org/10.1016/j.resp.2022.103920