Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease

Trypsin is a protease-activated receptor-2 (PAR2) activator that upregulates the interleukin (IL)-17 receptor signal in the airway epithelial cells and amplifies the inflammatory response, but does not modify the growth kinetics of the metapneumovirus. How does the coronavirus spread from cell to ce...

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Detalles Bibliográficos
Autores principales: Chen, Hongyu, Huang, Shirong, Chen, Qingquan, Liu, Qicai, Lv, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107181/
https://www.ncbi.nlm.nih.gov/pubmed/35580821
http://dx.doi.org/10.1016/j.resp.2022.103920
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author Chen, Hongyu
Huang, Shirong
Chen, Qingquan
Liu, Qicai
Lv, Xiaoting
author_facet Chen, Hongyu
Huang, Shirong
Chen, Qingquan
Liu, Qicai
Lv, Xiaoting
author_sort Chen, Hongyu
collection PubMed
description Trypsin is a protease-activated receptor-2 (PAR2) activator that upregulates the interleukin (IL)-17 receptor signal in the airway epithelial cells and amplifies the inflammatory response, but does not modify the growth kinetics of the metapneumovirus. How does the coronavirus spread from cell to cell is yet an enigma. The present study analyzed the possible role of trypsin in the activation of coronavirus in vitro and in vivo. We found that the overexpression of trypsin in A549 cells upregulated IL-17 and angiotensin-converting enzyme (ACE). In the humanized transgenic mice, trypsin activated M1 macrophages. Together, our results suggested that the upregulation of trypsin may support a new pathway for coronavirus transmission in patients.
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spelling pubmed-91071812022-05-16 Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease Chen, Hongyu Huang, Shirong Chen, Qingquan Liu, Qicai Lv, Xiaoting Respir Physiol Neurobiol Short Communication Trypsin is a protease-activated receptor-2 (PAR2) activator that upregulates the interleukin (IL)-17 receptor signal in the airway epithelial cells and amplifies the inflammatory response, but does not modify the growth kinetics of the metapneumovirus. How does the coronavirus spread from cell to cell is yet an enigma. The present study analyzed the possible role of trypsin in the activation of coronavirus in vitro and in vivo. We found that the overexpression of trypsin in A549 cells upregulated IL-17 and angiotensin-converting enzyme (ACE). In the humanized transgenic mice, trypsin activated M1 macrophages. Together, our results suggested that the upregulation of trypsin may support a new pathway for coronavirus transmission in patients. The Authors. Published by Elsevier B.V. 2022-09 2022-05-14 /pmc/articles/PMC9107181/ /pubmed/35580821 http://dx.doi.org/10.1016/j.resp.2022.103920 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Chen, Hongyu
Huang, Shirong
Chen, Qingquan
Liu, Qicai
Lv, Xiaoting
Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease
title Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease
title_full Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease
title_fullStr Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease
title_full_unstemmed Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease
title_short Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease
title_sort trypsin may induce cytokine storm in m1 macrophages, resulting in critical coronavirus disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107181/
https://www.ncbi.nlm.nih.gov/pubmed/35580821
http://dx.doi.org/10.1016/j.resp.2022.103920
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