APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

Approximately half of Alzheimer’s disease (AD) brains have concomitant Lewy pathology at autopsy, suggesting that α-synuclein (α-SYN) aggregation is a regulated event in the pathogenesis of AD. Genome-wide association studies revealed that the ε4 allele of the apolipoprotein E (APOE4) gene, the stro...

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Detalles Bibliográficos
Autores principales: Jin, Yunjung, Li, Fuyao, Sonoustoun, Berkiye, Kondru, Naveen Chandra, Martens, Yuka A., Qiao, Wenhui, Heckman, Michael G., Ikezu, Tadafumi C., Li, Zonghua, Burgess, Jeremy D., Amerna, Danilyn, O’Leary, Justin, DeTure, Michael A., Zhao, Jing, McLean, Pamela J., Dickson, Dennis W., Ross, Owen A., Bu, Guojun, Zhao, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107450/
https://www.ncbi.nlm.nih.gov/pubmed/35471463
http://dx.doi.org/10.1007/s00401-022-02421-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107450/
https://www.ncbi.nlm.nih.gov/pubmed/35471463
http://dx.doi.org/10.1007/s00401-022-02421-8

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